Solubility test for Hb S.

Rapid solubility test for detection of hemoglobin S.

Several screening methods for detecting sickling hemoglobins are presently used in the clinical laboratory (1-6). The present procedure depends on the insolubility of reduced hemoglobin S in a 2.24 mol/liter phosphate buffer. The commercially available “Sickledex” (Ortho Diagnostics, Raritan, N.J. 08869) is also thought to be based on this principle (6). Our method was compared with the standar...

A case of compound heterozygosity for Hb S and Hb S Oman.

The haematological and clinical findings of a three year old Omani girl, phenotypically compound heterozygote for Hb S and Hb S Oman, are presented, further substantiated by family studies. The necessity of reviewing cases with sickle cell haemoglobin in Oman is stressed.

Hb in Diabetic Patients with Normal ( Hb A ) and Abnormal ( Hb S and Hb C ) Hemoglobins , as Measured

In a recent study (1 ) of diabetic patients with hemoglobins S and C (Hb S and Hb C), we showed a significant decrease in the proportion of glycosylated Hb, as measured by cation-exchange chromatography. We suggested ( I ) that these low values for glycosylated Hb might be caused by the inability of either Hb S or Hb C to undergo glycosylation or by their failure to be eluted from the column wi...

A rapid bile solubility test for pneumococci.

The observation that pneumococci when grown in an anaerobic atmosphere with 10% CO2 produce characteristically large colonies (Howden, 1976) called for a simple rapid confirmatory test; in this way a precise report could be issued on the morning of isolation. Hawn and Beebe (1965) described a solubility test for aerobic pneumococcal colonies using a sodium deoxycholate solution (pH 70). Aerobic...

False positive results with a rapid solubility test for haemoglobin S.